Suominen P, Möttönen T, Rajamäki A, Irjala K. Single values of serum transferrin receptor and transferrin receptor ferritin index can be used to detect true and functional iron deficiency in rheumatoid arthritis patients with anemia. May still be iron deficiency anemia since ferritin is an acute phase reactant. Rimon E, Levy S, Sapir A, et al. Arthritis Rheum 2000; 43:1016. Rimon E, Levy S, Sapir A, et al. Diagnosis of iron deficiency: Transferrin saturation (tsat) <19%, Ferritin <30 ng/mL (normal range is 40-200). sTfR and ferritin were used to …

As the body does not have a way to excrete excess iron, there is a progressive buildup of iron in tissues and organs. Many sources use a ferritin cutoff of <15 ng/mL. 3.2.5 Soluble transferrin receptor (sTfR). soluble transferrin receptor (TfR), are influenced by changes in the concentration of acute phase proteins (APPs) during infection or trauma. Next steps: – Check TIBC, serum iron, transferrin saturation Still confused: – Serum (or “soluble”) transferrin receptor – increased in iron deficiency, but not as sensitive or specific …

In contrast, soluble transferrin receptor (sTfR) has been shown to be an indicator of iron deficiency and is unaffected by concomitant chronic disease and inflammation [5-13]. Hemochromatosis is an iron metabolism disorder that may be inherited or acquired. The soluble transferrin receptor (sTfR) test is primarily ordered to help distinguish between anemia that is caused by iron deficiency and anemia that is caused by inflammation or a chronic illness (so-called anemia of chronic disease or inflammation). AU Cazzola M, Beguin Y, Bergamaschi G, Guarnone R, Cerani P, Barella S, Cao A, Galanello R SO Br J Haematol. We investigated whether serum sTfR levels can aid in diagnosis and treatment of iron deficiency anemia (IDA) in children. The transferrin receptor (TfR) is a homodimeric type II membrane protein that mediates iron uptake into the cells. It is useful at discriminating iron deficiency in difficult cases, for instance, in patients with chronic renal failure or chronic inflammation like rheumatoid arthritis. Intra-erythrocytic ferritin and erythrocyte zinc-protoporphyrin also help to differentiate IDA from ACD. Diagnosis of iron deficiency anemia in the elderly by transferrin receptor-ferritin index. It is unchanged in anaemia of chronic disease. 2002;162(4):445–449. Concentrations of serum sTfR are related to iron status and erythropoiesis in the body. The soluble transferrin receptor test is not a routinely order test, but since it is not an acute phase reactant, it may be ordered as an alternative to ferritin to evaluate stored iron when a chronic illness is present or suspected. UpToDate, electronic clinical ... Medline ® Abstract for Reference 108 of 'Causes and diagnosis of iron deficiency and iron deficiency anemia in adults' 108 ... Soluble transferrin receptor (sTfR) and ferritin concentrations were measured in a variety of clinical settings to compare the ability of these two tests to identify iron deficiency. Soluble transferrin receptor (sTfR) is not an acute phase reactant. Suega K, Kandarini Y, Tubung J. Means RT Jr. Advances in the anemia of chronic disease. A more specific test for iron deficiency is the ratio of plasma Soluble transferrin receptor to serum Ferritin. 1999;106(3):752. Reticulocyte haemoglobin content (<29 pg) is an alternative.14 Red cell zinc protoporphyrin, soluble transferrin receptor, and the soluble transferrin receptor log ferritin ratio have been proposed as markers of functional iron deficiency. Briefly, the soluble transferrin receptor (sTfR) (reference range: 0.76–1.76 mg/L) and C-reactive protein (CRP) (reference range: 0–3 mg/L) were determined by nephelometric methods, ferritin (reference range: men: 26–388 ng/mL, women: 8–252 ng/mL) by sandwich chemiluminescent immunoassay on Dimension Vista System (Siemens, Vienna, Austria). An additional iron index is the soluble transferrin receptor (sTfR) concentration, which is elevated in tissue iron deficiency and not sensitive to inflammation; the sTfR/log ferritin ratio is highly correlated with body iron stores.28 However, sTfR estimation is limited by variability in interassay cut-offs, availability and slow turnaround in some laboratories. Ferritin is an acute phase reactant that becomes elevated during inflammation. 2019Jan.13 [cited 2020Jun.2];7(1):97-102. We performed sensitivity analyses using the transferrin:log(ferritin) ratio with a cutoff value of 1.70 as an alternative method to diagnose iron deficiency in the context of inflammation (27, 28 Int J Hematol 1999; 70:7. People with hemochromatosis accumulate more iron than their body needs.